Best Science And Engineering Companies in Minnesota (2021)

Medtronic

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Medtronic develops healthcare technology to treat chronic diseases. Its medical technology is providing lifelong solutions for people with chronic pain.

The company is committed to improving lives through its medical technologies, services, and solutions. Medtronic has four main business units: the Minimally Invasive Therapies Group, the Diabetes Group, the Restorative Therapies Group, and the Cardiac and Vascular Group.

Medtronic develops and manufactures devices and therapies to treat more than 30 chronic diseases that include heart failure, Parkinson disease, urinary incontinence, Down syndrome, obesity, chronic pain, spinal disorders, and diabetes. Medtronic was founded in 1949 and is headquartered in Minneapolis, Minnesota, United States.

Mayo Clinic

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Mayo Clinic, a not-for-profit medical group practice, provides medical care, research, and education services in Minnesota, Florida, Arizona, Iowa, Georgia, and Wisconsin. It offers medical care services in various specialties, including diabetes and endocrinology, gastroenterology, gynecology, cancer, neurology and neurosurgery, orthopedics, pulmonology, rheumatology, nephrology, urology, and cardiology and heart surgery.

The company operates a network of care center in the United States. It also provides medical education services through schools, offering various degree or certificate programs in continuing medical education, doctoral, master’s, and health sciences.

In addition, the company conducts basic, translational, clinical, and epidemiological research activities to develop diagnostic tools, medications, devices, and treatment protocols. Further, it offers online services to patients, health care providers, and employees.

The company was formerly known as Mayo Clinic Rochester and changed its name to Mayo Clinic in 2009. Mayo Clinic was founded in 1919 and is based in Scottsdale, Arizona.

It has locations in Arizona, Florida, and Minnesota. Mayo Clinic operates as a subsidiary of Mayo Foundation For Medical Education And Research..

MIVI Neuroscience

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MIVI Neuroscience focuses on developing and commercializing clinical solutions for neurointerventional procedures. Their innovative product portfolio provides physicians with unique devices that improve patient outcomes by reducing complications, shortening procedure times, and expanding treatment to more patients.

The company was founded in 2013 and is headquartered in Eden Prairie, Minnesota.. .

Central Logic

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Central Logic is the healthcare industry’s leading provider of innovative transfer center and bed management solutions. The company’s growth is fueled by its ability to replace antiquated software in forward-thinking hospitals and medical systems.

Its flexible, purpose-built access and orchestration solutions ensure efficient patient navigation across health systems and through the continuum of care and deliver the necessary controls to elevate revenue capture, clinician effectiveness, and patient outcomes. Central Logic’s customers include HCA, Cleveland Clinic, Sutter Health, Memorial Hermann, Baptist Health South Florida, and hundreds more.

It has been named a “fastest-growing private company” by both Inc. 500 and Utah Business Magazine.

It was founded in 2005 and headquartered in St. Paul, Minnesota by Darin Vercillo, Ryan Larsen, and Scott Jordan..

Inspire Medical Systems

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Inspire Medical Systems develops implantable therapeutic devices for the treatment of obstructive sleep apnea.

CVRx

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CVRx is a medical device company that develops implantable technology for the treatment of high blood pressure. Its products include Rheos implantable pulse generator that provides control and delivery of the activation energy; and Rheos carotid sinus leads, which conducts activation energy from the Rheos implantable pulse generator to the left and right carotid arteries.

The company also offers a Rheos programmer system that communicates with the Rheos pulse generator. CVRx was founded in 2001 and is based in Minneapolis, Minnesota..

Vireo Health

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Vireo Health is a physician-led company dedicated to providing patients with best-in-class cannabis-based products and high quality care Vireo Health, we believe medical marijuana is a great resource for treating a variety of qualifying conditions safely. By speaking with our patients about their diagnoses and their medical care, we’ll work together with the patient and their physician to craft a treatment plan that keeps the patient front and center.

When you visit our New York medical marijuana dispensary, you’ll find compassionate physicians and pharmacists who are up-to-date on cannabis-based remedies and who understand the differences between the various capsules, oral solutions, vaporization cartridges, and vaporization oils we prescribe. Together, you’ll be able to decide which product may be right for you as we work to manage your condition.

Our best-in-class cannabis-based products are truly made with our patients in mind. As an integrated medical marijuana dispensary, we handle everything from seed to sale.

Our knowledgeable staff of horticulturalists and scientists nurture our plants and create our products, while our compassionate physicians and pharmacists assist patients in our dispensaries.. .

Sentera

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Sentera is provides decision support and insights to growers, advisors, and enterprise customers. Our products use machine learning, modeling, and data sciences tools to gather data, organize it, and quickly turn it into insights that improve outcomes for growers, advisors, and retailers.

We deliver the best insights from high-resolution drone imagery, satellites, field equipment, and other sensors, and combine it with advanced modeling and analytics tools at scale.. .

StemoniX

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StemoniX is a biotechnology company that focuses on stem cell technologies to meet the demands of drug discovery and personalized medicine. StemoniX is revolutionizing the production, growth, and development of stem cell and stem cell technologies.

It was founded in 2014 and headquartered in Maple Grove, Minnesota.. .

Relievant Medsystems

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Relievant provides patients with low risk therapy that affords the ability to alleviate their back pain.

Perforce Software

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Perforce Software helps companies build complex products more collaboratively and securely. Its highly scalable source code management (SCM) and collaboration platform, Perforce Helix, enables global teams to collaborate on any type or size of file, from code to CAD designs to environment configurations.

Helix supports both centralized and distributed (DVCS) workflows while safeguarding intellectual property with advanced behavioral analytics. Perforce serves more than 15,000 customers, from start-ups to some of the most innovative brands in the world, including adidas, Samsung, NVIDIA, Intuit, Pixar, Salesforce, EA, Ubisoft, and VMware.

The company is headquartered in Eden Prairie, Minnesota, with offices in California, the United Kingdom, Canada and Australia, and sales partners around the globe.. .

Calyxt

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Calyxt is an Agbiotech company focused on developing crops with healthier characteristics. Capitalizing on its team and new technologies, the company’s mission is to develop a novel generation of crops that will help develop food products with more health benefit for consumers.

Our business philosophy is to focus on developing products and maximizing value through partnerships.Our motto is “Healthier Food for a Better Life. .

Recombinetics

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Recombinetics targets biomedical and regenerative medicine, opening vast new opportunities to improve and extend human life.

Spoonshot

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Spoonshot is a developer of a personal discovery platform used to replicate human cognition in the food domain. It delivers food and beverage innovation intelligence by leveraging AI and food science.

The company’s insights reveal the future of food through a deep understanding of emerging and evolving consumer and market needs, enabling Spoonshot to accurately predict trends and uncover innovation opportunities.. .

NatureWorks

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NatureWorks LLC is a company dedicated to meeting the world’s needs today without compromising the earth’s ability to meet the needs of tomorrow. With a current Ingeo capacity of 140,000 tons, NatureWorks LLC is the first company to offer a family of commercially available low carbon footprint biopolymers derived from 100 percent annually renewable resources with performance and economics that compete with oil-based plastics and fibers.

NatureWorks production of Ingeo uses significantly less non-renewable energy, and generates significantly lower CO2 emissions than all traditional oil based polymers. NatureWorks remains wholly owned by Cargill pending regulatory approval of the agreement..

Nuvaira

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Nuvaira is a new alternative COPD treatment option that specializes in developing devices for treating lung diseases. Nuvaira is currently working on a novel catheter-based system that has the potential to improve lung function, exercise capacity, and quality of life for patients with chronic obstructive pulmonary disease.

It was founded in 2008 and headquartered in Minneapolis, Minnesota.. .

Neuroone Medical Technologies

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NeuroOne is a medical technology company focused on improving surgical care for patients suffering from neurological disorders.

Ativa Medical

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Ativa Medical is a medical device manufacturing company that is working to make diagnostic test results available in moments, rather than hours and days. The company specializes in the fields of medical device development, point of care diagnostics, microfluidics, and hematology.

The company was founded in 2008 and headquartered in Saint Paul, Minnesota.. .

Conventus Orthopaedics

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Conventus Orthopaedics provides a range of orthopedic and sports medicine services. The physicians specialize in orthopedic surgery, reconstructive surgery, spine surgery, joint replacement, sports medicine, physical therapy, and operative care of fractures, arthritis, strains, sprains, and sports-related injuries.

Conventus was formed by a team of medical professionals with the sole purpose of creating less invasive ways to treat challenging periarticular fractures. By leveraging advanced nitinol technology, the Conventus team has developed a platform technology that provides robust fixation and creates reliable repairs.

The company was incorporated in 2009 and is based in Maple Grove, Minnesota.. .

NimbeLink

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NimbeLink is a provider of cellular modems, cellular gateway systems, and developer services, specifically to small- and medium-sized companies in the machine-to-machine (M2M) connectivity market. Its Skywire modems and related software and services enable OEM customers to easily develop end-device certified IoT solutions for faster time to market.

Founded in 2013, Minnesota-based NimbeLink has brought together award-winning engineers and designers of embedded systems to develop products for and provide services to, companies developing technology for the Internet.. .

Luminary Therapeutics

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Luminary Therapeutic is a cancer research center that develops pre-clinical stage cell therapy for cancer and autoimmune diseases. It creates an engine that completes novel and early therapeutic discovery through Phase I clinical trial completion, enabling doctors to eliminate viral-based cell therapy issues.

The company was founded in 2019 and is based in Minneapolis, Minnesota.. .

NeoChord

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NeoChord is a medical device company that has developed a proprietary device that allows mitral valve repair to be performed on a beating heart through a 2 to 3-inch incision between the ribs in patients with severe, degenerative mitral valve regurgitation. In contrast, most mitral valve repair procedures are performed through a 3 to 10-inch chest incision (sternotomy) which involves cutting through the sternum, opening the rib cage, stopping the heart and placing the patient on bypass.

Founded in 2007 and is based in St. Louis Park, MN..

Cardiovascular Systems

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Cardiovascular Systems, Inc. (CSI) is devoted to developing and commercializing innovative solutions for treating peripheral and coronary vascular disease.

Their primary focus is helping physicians conquer even the most difficult disease states, including calcium, given the complications it presents for the millions who suffer from peripheral arterial disease (PAD) and coronary artery disease (CAD). CSI is committed to clinical rigor, constant innovation, and a defining drive to set the standard in safe, effective, economical medical devices that improve patient outcomes..

Entellus Medical

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Entellus Medical is focused on providing unique solutions to the unmet needs of the ENT (ear, nose and throat) physician, their patients, and payers through the development of innovative device technology and treatment solutions. Entellus is based in Maple Grove, MN and markets products throughout the United States.

Entellus Medical works closely with leading researchers and clinicians to develop solutions that benefit patients, physicians, and payers. Entellus provides a simple, direct and effective treatment for Chronic Rhinosinusitis (CRS) that is less invasive, reduces pain and bleeding, shortens recovery time, and eliminates the need for general anesthesia.

Entellus recently introduced FinESSâ„¢ Sinus Treatment, a simple and direct approach to effectively treat patients with CRS. FinESS can be performed under local anesthesia, with or without light sedation, and remodels the maxillary ostium and the ethmoid infundibulum using a micro endoscope and a small balloon catheter.

Unlike sinus surgery techniques, FinESS does not require the removal of delicate bone or sinus tissue, resulting in shorter treatment time with very little pain or bleeding. Recovery time is usually one to two days with many patients resuming normal activity within a day..

CHF Solutions

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CHF Solutions focuses on an innovative cardiac assist therapy to treat patients with heart failure and related conditions. Unfortunately, these Class IV patients, despite optimal drug therapy, have persistent symptoms and their options are very limited.

Surgical approaches usually involve complex open-heart surgery or heart transplantation. Sunshine Heart’s C-Pulse® Heart Assist System is an innovative approach to assist the heart’s function, not replace it, and maybe implanted using a minimally invasive approach.

The C-Pulse Heart Assist System is designed to treat clinical symptoms associated with Class III and ambulatory Class IV heart failure, sometimes also referred to as moderate and severe failure. Patients associated with Class III and ambulatory Class IV heart failure are typically unable to engage in normal activities, compromising their quality of life.

The C-Pulse System uses proven balloon counter-pulsation technology to assist the heart by reducing the workload of the left ventricle. During inflation of the balloon, blood flow is increased to the coronary arteries, thereby providing additional oxygen which is vital to a failing heart.

During deflation, the workload, or pumping required by the left heart is reduced. The balloon inflation and deflation are synchronized to the patient’s heartbeat, similar to a pacemaker.

Potential benefits of the technology are relief of shortness of breath, increased physical activity, improved cardiac function, enhanced mobility, and improved quality of life. Physicians have commented that patients experience some of these benefits almost immediately after device placement..

BioAmber

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BioAmber is a private US company registered in the state of Delaware. The company, formerly known as DNP Green Technology, changed its name to BioAmber following its acquisition of its joint venture with ARD.

Following the transaction, they adopted the name BioAmber, which had been used to that point by the joint venture.. .

NxThera

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NxThera develops medical technologies to treat a variety of endourology conditions, including BPH. The company’s technology platform utilizes a simple, minimally invasive, vapor therapy designed to measurably improve urinary flow and patient quality of life.

BPH afflicts more than 32 million men in the United States.. .

Miromatrix Medical

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Miromatrix Medical is engaged in the development of fully biological human organs and organ-derived biological products.

EnteroMedics

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EnteroMedics® Inc. is the developer of vBloc® neurometabolic therapy, delivered by a pacemaker-like device called the Maestro® Rechargeable System, a first-in-class weight loss treatment for obesity and obesity related risk factors, such as high blood pressure or high cholesterol levels.

vBloc Therapy is a non-anatomy altering or restricting, reversible therapy that allows patients to safely lose weight by helping patients feel less hungry, reduce the amount of food eaten at a meal, and feel full longer in between meals.. .

Rebiotix

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Rebiotix is a development-stage biotechnology company focusing on the treatment of GI diseases by developing human microbiome.

Biothera

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Biothera, Inc., a biotechnology company, develops a natural gluco polysaccharide that engages and directs natural innate immune systems. Biothera was formerly known as Biopolymer Engineering, Inc.

and changed its name to Biothera, Inc. in March 2005.

The company was founded in 1997 and is based in Eagan, Minnesota.. .

Imbio

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Imbio, we focus on bringing imaging biomarkers pioneered in the academic research world to clinical practice. We work closely with our academic partners to offer applications based on cutting-edge and rigorous research.

We bridge the gap from bench to bedside by refining biomarker algorithms beyond the initial prove-out stage, and working under accredited design controls to create commercial medical software.. .

ANI Pharmaceuticals

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ANI Pharmaceuticals is a specialty pharmaceuticals industry, ANI Pharmaceuticals develops, manufactures and markets top quality prescription pharmaceuticals, made in the U.S.A. ANI manufactures oral solid dose products, as well as liquids and topicals, including narcotics and those that must be manufactured in a fully contained environment due to their potency and/or toxicity.

ANI also performs contract manufacturing for other pharmaceutical companies.. .

Metavention

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Metavention develops medical devices to help with interventional therapies for Type 2 diabetes.

Vyriad

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Vyriad is a clinical stage biopharmaceutical company.

GeneMatters

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GeneMatters delivers genetic counseling services for hospitals, health networks, clinics, academic research centers, and genetic testing labs. The company is the operator of an online genetic counseling network intended for providing genetic counseling and caregiving services.

The company’s genetic counseling network facilitates pre-test counseling, full-service genetic counseling, and caregiving services for people seeking genetic insights, enabling users in understanding their genetic family history and make informed decisions based on genetic tests. GeneMatters was established in 2016 and is based in Minneapolis, Minnesota, United States..

CloudCover

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CloudCover is a full-spectrum cyber security extended threat detection platform utilizing AI-based machine learning to deliver real time security awareness and automated security protection. Our platform employs network analytics including risk score that enables the underwriting of incremental cybersecurity data insurance on-demand.

CloudCover deploys as an AI-enhanced Security Orchestration Automation Risk Response (SOAR) network solution operating in microsecond speed at over nine-nines (99.9999999%) accuracy. Our CC/B1 extends onto a customer’s network as real-time sensors and therein utilizing AI/ML is capable of detecting-anticipating known, unseen and previously unknown threats at the network computing edge.

The CC/B1 is module-based and may be custom configured into practically any network enterprise, telco and/or edge computing security device. Since inception, our CyberSafety Platform represents the most advance cybersecurity solution in the market today.

CloudCover’s technology portfolio has integrated artificial intelligent systems and methods including blockchain technology that will revolutionize the unique protection that represent our cyber safety platform. We are transforming traditional data security and privacy methods into real time insured cyber safe, compliant ecosystems..

OneOme

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A partnership of the Mayo Clinic & Invenshure, OneOme analyzes patient DNA via the most complex multi-gene algorithm in the marketplace. Working with physicians and health care providers, we minimize errors and failures and advance efficacy and safety.

Applied across the majority of pharmaceutical medicine, the result is an actionable, at-a-glance prescription recommendation report that is absolutely personalized to each patient. The next level of pharmaceutical efficiency and safety is here..

Cogentix Medical

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Cogentix Medical products have increased treatment efficiency and lowered patient risk. Macroplastique® established the European market for bulking agents, EndoSheath® protective barrier redefined endoscopy and Urgent® PC set the standard for percutaneous tibial nerve stimulation (PTNS) as a treatment for Overactive Bladder.

Cogentix Medical was formed in 2015 following a merger of Uroplasty and Vision-Sciences.. .

Rover Robotics

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Manufactures industrial grade ROS enabled robots

Cymbet

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Cymbet develops market eco-friendly, biocompatible rechargeable solid state batteries that provide electronic systems designers with new embedded power capabilities. Cymbet’s EnerChip batteries allow new concepts in energy storage application for ICs and new products for medical, sensor, RFID, industrial control, communications, and portable electronic devices.

Their new single chip Power Management Real-Time Clock (PMRTC) device is a world class device and among the lowest power RTCs in the industry.. .

Silk Technologies

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SILKTECH focuses on innovating and developing silk-derived protein (SDP) products for ophthalmic applications. The company’s patented SDP material is currently being developed as a novel compound for the treatment of patients with dry eye disease.

SILKTECH is based in Plymouth, MN and is financially backed by a combination of angels, grants and recently from a financing round by Skyview Ventures .. .

Equals 3

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Equals 3 creates advertising and marketing solutions leveraging the cognitive computing power of IBM’s Watson. It is part of a community of over 80,000 developers building with the dozens of APIs available on the open Watson Developer Cloud platform.

Equals 3 also joins 500 developer partners who have created novel apps and businesses using with Watson APIs, 100 of which have commercialized solutions. the company was founded in 2015 and is headquartered in Minneapolis, Minnesota..

Tendyne Holdings

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Tendyne Holdings, Inc. is a clinical stage medical device company focused on the development of minimally invasive therapies for the treatment of mitral regurgitation.

Mitral regurgitation is a condition that afflicts hundreds of thousands of individuals worldwide every year. Formed in 2010, their first product concept is a transcatheter mitral valve replacement prosthesis for the treatment of mitral regurgitation.

The intent is for the valve to be deployed and secured with no disruption to the native mitral annulus while preserving the sub-valvular apparatus. Placement of the valve is intended to be completed transapically in a simple procedure where the implanting physician is able to re-position, remove, and re-deploy their valve throughout the procedure..

Torax Medical

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Torax Medical, Inc., a clinical stage medical device company, develops an implantable device for the treatment of gastroesophageal reflux disease. It provides treatments for digestive diseases, including acid reflux.

The company was founded in 2002 and is based in Shoreview, Minnesota.. .

Osprey Medical

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Osprey Medical is a medical device company incorporated in 2005 with operations based Minnetonka, Minnesota, USA. The Company is focused on the development and commercialization of its propriety CINCOR™ System designed for the prevention of Contrast Induced Nephropathy (CIN).

The CINCOR™ System originated from technology developed at the Baker Heart and Diabetes Institute in Melbourne, Australia.. .

Panbela Therapeutics

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Panbela Therapeutics is a next-generation biopharmaceutical company developing disruptive therapeutics for serious unmet medical needs. The company’s initial programs are aimed at diseases of the pancreas, including pancreatic cancer and pancreatitis.

Panbela Therapeutics has scientific collaborations with pancreatic disease experts at Honor Health in Scottsdale, AZ, Cedars Sinai Medical Center in Los Angeles, the University of Minnesota, Mayo Clinic Scottsdale, the Austin Health Cancer Trials Centre, and the Ashford Cancer Centre in Adelaide, Australia.. .

Venture Med Group

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VentureMed Group (VMG) designs, develops and markets innovative medical devices which enable interventionalists to cost effectively treat peripheral artery diseases and improve the lives of their patients. Founded by physicians who understand the clinical, medical and financial demands in today’s healthcare environment, VMG creates truly cost effective solutions.

Their flagship product, the FLEX Scoring Catheter enables providers to reduce expensive inventory costs while offering the interventionalist more treatment options from a single device.. .

Rotation Medical

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Rotation Medical Inc. manufactures and markets a collagen scaffold for rotational cuff disease in Minnesota.

The company was formerly known as Denali Medical Inc. and changed its name to Rotation Medical Inc.

in March 2010. Rotation Medical was founded in 2009 and headquartered in Plymouth, Minnesota..

Cryosa

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CryOSA is a medical device company developing novel treatments for obstructive sleep apnea.

DiaMedica

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DiaMedica (TSX-V:DMA) is a biopharmaceutical company focused on developing innovative treatments for stroke and other vascular diseases where no current therapies are available. The only universally approved stroke treatment is tissue plasminogen activator (tPA) which can only be administered to patients within 4.5 hours of acute ischemic stroke.

However, a urine-derived form of human tissue kallikrein-1 (uKLK1) has been approved in China for up to 48 hours post-stroke by promoting cerebral vascular circulation, angiogenesis and inhibiting apoptosis. Published clinical studies have found uKLK1 is also effective in combination with tPA in stroke patients.

DiaMedica’s DM199 has been administered to close to 100 patients and demonstrated a safe and well tolerated profile. The Company is preparing to advance its proprietary recombinant form of the naturally occurring uKLK1 into clinical testing for the treatment of stroke.

The Company is also studying the potential of DM199 for the treatment of acute kidney injury and other vascular diseases.. .

CardiaLen

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CardiaLen develops and commercializes pain-free cardioversion therapies for atrial fibrillation. The company is developing implantable low-energy (low voltage) pain-free atrial cardioverters to help address the major unmet needs of this condition.

It was founded in 2008 and headquartered in Minneapolis, Minnesota.. .

Preceptis Medical

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Preceptis Medical is a medical device manufacturer developing surgical tools that allow ear tube procedures to be performed with reduced pain and surgical time for the pediatric patient. Its pediatric surgical technology Hummingbird TTS offers an alternative to general anesthesia and minimizes surgical trauma during ear tube placement, enabling physicians to use moderate sedation for routine ear tube procedures.

Preceptis Medical was founded in 2011 and is headquartered in Maple Grove, Minnesota.. .

Geneticure

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Geneticure is a personalized medicine company with patented tests that control chronic diseases faster than trial/error, with less cost

AUM Cardiovascular

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AUM Cardiovascular is a medical device manufacturing company that specializes in the fields of biotechnology, medical, and healthcare. Its system provides an office-based, fast-test interaction between the patient and their clinician.

The company was founded in 2009 and is headquartered in Beaver Creek, Minnesota.. .

Imricor Medical Systems

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Imricor Medical Systems develops magnetic resonance imaging (MRI) compatible electrophysiology tools for the treatment of cardiac arrhythmias. The company offers Vision MR EP Ablation Catheter that looks and performs as a conventional ablation catheter; and Horizon MR EP Recording System, which performs the recording and pacing function of conventional recording and pacing systems for use with MRI.

Its products allow electrophysiologists to perform cardiac electrophysiology procedures in the MRI lab to image a patient’s heart.. .

Tempore

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At Tempore, we have made it our mission to create the most loved user experience in business travel. The fruits of our labor come in the way of an artificial intelligence engine named Tempore.

Modeled after the user experience of a well-trained executive assistant, Tempore learns your travel habits and integrates directly with your calendar to reduce the complex and verbose act of booking business travel down to just… one single click.

So we only have one question: “Are you tired of booking business travel the ‘old-fashioned’ way?”… The most exclusive boarding pass in business travel is only a few clicks away! Request access to our private pilot program at https://www.tempore.com.

Civil Site Group

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Civil Site Group provides professional civil engineering, landscape architectural, and site development consulting services. Our portfolio of projects includes sites both large and small.

We are currently designing and engineering. The company was founded in 2011 and headquartered in St.

Louis Park, Minnesota.. .

EmboMedics

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EmboMedics, Inc. develops and commercializes resorbable and drug-loaded embolization devices for the treatment of multiple indications.

The company was founded in 2012 and is based in Maple Grove, Minnesota.. .

Geronimo Energy

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American full-service renewable energy company .

MicroOptx

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MicroOptx is an early-stage medical device company that leverages academic bioengineering, surgical expertise, microengineering manufacturing, and nanotechnology to provide the modern solution for the vexing problem of Glaucoma. It develops a platform technology to shunt aqueous humor from the anterior chamber to the surface of the eye.

The company is driven by a mission is to change the way the world treats glaucoma: and to halt the devastating effects of this progressive disease. MicroOptx is led by recognized medical, industry and financial veterans who are dedicated to preventing blindness..

Celcuity

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Celcuity transform care for patients with cancer or autoimmune disease. They are developing a range of tests in several disease areas that enable clinicians to understand whether a drug therapy’s mechanism of action is functional ex vivo in their patient’s diseased cells.

It was founded in 2012 and headquartered in Hamel, Minnesota.. .

SENSE AI

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Sense AI Inc. offers an SDK for developers who want to integrate the ability to take environmental measurements (ambient temperature, altitude, pressure, light, and more) as well as state detection (in hand, in pocket, inside vs.

outside, and more) into their own applications. It also offers developers access to a data analysis portal with insights from the data their users generate.

Sense AI is also the maker of Kelvin Sense, an application that turns mobile devices into thermometers and measures the temperature. The company was incorporated in 2015 and is based in St.

Paul, Minnesota.. .

Segetis

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Segetis, Inc., a green chemistry company, engages in the development, production, and commercialization of renewable polymers. The company focuses on a platform of binary monomers based on renewable feed stocks.

The company’s technology enables the use of non-food agricultural and forestry feed stocks for the production of various materials, as well as enables the second wave of industrial bioproducts, such as bio-plastics, surfactants, plasticizers, adhesives, coalescent solvents, and other compounds for specialty chemical applications. Its chemistries offer various opportunities for product enablement and synergies for industries engaged in the processing of starch and sugar crops; processing of wood, cellulose, and paper pulp; chemical processing of vegetable oils; manufacturing of biodiesel; and the manufacturing of linear alpha-olefins and other compounds.

The company was founded in 2006 and is based in Golden Valley, Minnesota.. .

CoreBiome

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CoreBiome provides fast, accurate genomic profiles of microbial communities (microbiomes) to customers in pharmaceutical, agriculture, and academic research. Their proprietary reagents and informatics uniquely enable rapid, affordable, and highly accurate measurement and interpretation of microbial diversity.

CoreBiome provides expert genomics and informatics for the entire microbiome industry, accelerating discovery and unlocking the translational potential of the microbiome in medicine, agriculture, and other fields. ​.

CranioVation

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CranioVation is an innovative solution to treat aggressive brain tumors using light delivered via a minimally invasive device.

Pluralytics

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Pluralytics is the first language intelligence solution powered by people’s values. We provide deep intelligence: from your email campaigns to your social content to your web presence.

Our platform “reads” content, tells you who it appeals to – and why – and then recommends changes to appeal to more people. Our leading-edge approach is rooted in behavioral science and machine learning and identifies whether a company speaks effectively to its values-driven customers.

In a deeply fragmented polarized marketplace, more than 50% of all consumers are values-based consumers. Almost every word we choose conveys values.

Choose wisely. Using analyses of over 20 million words and counting, we successfully tested our prototype with a Fortune 500 innovator and invented time-sensitive values words analysis insights on unfolding events like the COVID-19 pandemic.

Leading-edge experts in the field have praised our methods. The Creative Destruction Lab (CDL) —a highly competitive, seed stage program for massively scalable science-based start-ups, recently selected Pluralytics to join their AI stream.

With accelerators at Oxford University, Paris, Toronto and Atlanta, CDL works with startups that employ innovations in technology and business models that promise a chance of delivering massive improvements to economic productivity and human welfare.. .

Boon Logic

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BoonLogic is machine learning technology startup

Reprise Biomedical

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Reprise Biomedical, Inc. is a Minnesota-based startup focused on commercializing biological medical devices manufactured using a proprietary perfusion decellularization technology that supports cellular integration.

Reprise was created in connection with a spin-off from Miromatrix Medical Inc. in June 2019.

Through the spin-off, Miromatrix transferred to Reprise two existing FDA 510(k) cleared, commercially available medical devices – MIROMESH® Biologic Matrix and MIRODERM® Biologic Wound Matrix – as well as all acellular medical devices in development. MIROMESH and MIRODERM are derived via perfusion decellularization of the highly vascularized porcine liver.

A non-crosslinked surgical mesh, MIROMESH comes in a variety of sizes suited for hernia repair applications. MIRODERM is indicated for the management of wounds, including diabetic foot ulcers, venous ulcers, pressure ulcers, and surgical and trauma wounds..

Vergent Bioscience

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While the complete removal of residual cancer at the tumor margins during the surgical resection of solid tumors is closely linked with improved cure rates, it is often difficult for even experienced surgeons to distinguish cancerous tissue from normal tissue. Visual differentiation is needed at the cellular level.

Vergent’s molecularly-targeted imaging molecule, VGT-309, binds to enzymes that are overexpressed in tumor tissue, activating a brightly fluorescing dye. This proprietary molecule can identify and bind to multiple cancers including lung, breast, ovarian, colorectal, and brain, among others.

When injected prior to surgery, VGT-309 “lights up” cancerous tissue and gives the surgeon a clear visual guide for the removal procedure. Vergent’s approach directly addresses the clinical need and market opportunity for advanced visualization in open, laparoscopic, and robotic surgery procedures, while uniquely retaining the pricing flexibility required for success in a value-based healthcare system..

Humanetics Corporation

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Humanetics is a privately held, clinical stage pharmaceutical company located in the Minneapolis metropolitan area. The Company was founded in 1988 and is engaged in developing and commercializing products to enhance human health and wellbeing.

Humanetics entered the field of radiation modulators in 2003, through a cooperative research program with the Armed Forces Radiobiology Research Institute (AFRRI). Humanetics began working with AFRRI to test an array of drug candidates using their highly developed capabilities.

From this program, BIO 300 emerged as a lead candidate and the underlying technology was in-licensed from AFRRI to Humanetics. In the ensuing years, the Company has progressed this program into multiple clinical uses with a primary focus on improving treatment of solid tumor cancers..

DeZURIK

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DeZURIK is an industrial company that designs and manufactures valves for the water and wastewater treatment industry. The company’s product line has extended beyond the paper industry.

It specializes in valve technologies for water and wastewater treatment as well as industrial applications including pulp and paper, chemical and petrochemical, power, mining, and other process industries. DeZURIK operates a modern plant equipped with up-to-date production equipment that is devoted solely to the production of our valves and related products.

By applying their flow expertise through a broad portfolio of engineered valve solutions. The company was founded in 1925 and headquartered in Sartell, Minnesota..

Canomiks

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Canomiks’ genomics, bioinformatics, and AI-based Product Superiority Platform helps companies create safe and efficacious products.

Cardia

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Cardia is an innovative company engaged in developing, manufacturing and marketing transcatheter septal occluders. To date, they have closed over 15,000 septal defects worldwide.

Ultrasept, their latest family of products, serves as their 7th generation of septal closure devices. The dual articulating sails allow for easy deployment of the devices and create a super low profile within the atria.

Ultrasept devices boast a simple, hands-free loading feature and are fully retrievable before and after release. Ultrasept products include double-round devices for the percutaneous closure of both PFO’s (Patent Foramen Ovale) and ASD’s (Atrial Septal Defect).

A septal occluder is a cardiac implant that fixes a cardiac defect commonly referred to as a “hole in the heart.” Our devices are delivered through a catheter by an interventional cardiologist and only take about 30 minutes to the implant. Many patients are admitted to the hospital in the morning and return home that afternoon or the next day without the lengthy recovery periods often needed after open-heart surgery.

The market for their septal occluder products revolves around the need to close or fix a number of both pediatric and adult cardiac defects. The PFO (Patent Foramen Ovale) defect appears to occur in approximately 25% of the adult population.

Most people have no symptoms and therefore require no treatment; however, it is now believed that about 250,000-1,000,000 cases worldwide per year may require closure. These people initially experience a cryptogenic stroke and upon follow-up with their neurologists are revealed to have a PFO defect.

Veravas

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Veravas develops proprietary sample pretreatment products and new diagnostic tests to provide laboratories with high-value solutions for the accurate diagnoses of some of the world’s most devastating diseases. The company is also building new strategic collaborative partnerships to bring other diagnostic applications to the clinical in vitro diagnostics market.

Its proprietary sample preparation technology uses nanomagnetic beads that can be added to patient test samples. This core technology enables capture of specific substances for removal and to concentrate and quantify those factors for improved measurement of complex biomarkers..

Medical 21

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Develops and manufactures artificial graft for coronary bypass surgery.

St. Teresa Medical

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St. Teresa Medical, Inc.

is a medical device company commercializing a new hemostatic technology platform called FASTCLOT®. Dressings currently used to treat moderate and severe bleeding injuries caused by surgery, traumatic accidents or violence have limited clotting capabilities.

The patent-pending FASTCLOT® technology: (a) accelerates the clotting cascade by adding robust clot-forming proteins to an injury site, stopping bleeding faster and potentially saving lives; and (b) is the only fibrin-based clotting dressing with a rapidly dissolvable and absorbable delivery mechanism.. .

OX2 Therapeutics

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OX2 Therapeutics is a healthcare therapeutics company that focuses on treating brain tumors.

Gopher Resource

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Gopher Resource has been a national environmental solutions provider for nearly 70 years, protecting the earth and preserving natural resources. Their purpose is the safe and efficient recycling of lead-based batteries throughout North America using sustainable practices and advanced technology.

Gopher Resource is devoted to advancing safe, sustainable lead battery recycling. They’re proud of the recognition they’ve received for achieving high standards of environmental sustainability, safety, continuous improvement and product and service excellence.

To supply quality products and services to their customers through environmentally safe recycling. To be recognized as a leader in implementing innovative process improvements.

To enable all employees to realize personal and professional development through company-wide involvement, teamwork, open communications and training within a safe working environment.. .

Augustine Temperature Management

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Augustine Temperature Management develops and manufactures conductive fabric patient warming systems for surgical patients in the United States. Its products include a total access warming system that consists of a multi-function controller, a torso blanket, and an underbody mattress; a total versatility warming system that includes a multi-function controller and a multi-position blanket; and total efficiency warming system that consists of a multi-function controller and a full-body blanket.

The company markets its products through a network of dealers to clinicians and healthcare facilities. Augustine Temperature Management LLC was incorporated in 2008 and is based in Eden Prairie, Minnesota..

B-MoGen Biotechnologies

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B-MoGen Biotechnologies Inc is a genome engineering startup located in Minneapolis, Minnesota. Founded in 2015, B-MoGen has entered strategic partnerships with biotechnology companies, completed projects for clients in academia and industry, and successfully licensed and developed novel intellectual property focused on genome engineering.

B-MoGen Biotechnologies Inc offers custom tools for gene delivery and gene editing.. .

SpineThera

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SpineThera develops novel, sustained-release, injectable drugs to treat pain.

LHB

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LHB is an architecture and planning company that offers planning, engineering, and architectural services. They create a performance-based design; utilizing high-performance guidelines including ENERGYSTAR and LEED, and measuring success with Performance Metrics.

It was founded in 1966 and is based in Duluth, Minnesota.. .

Phenomix Sciences

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Phenomix Sciences is a biotechnology company that specializes in biotech, life science, metabolomics, and genomics. It provides healthcare solutions that will enable personalized management of chronic diseases with better efficacy, fewer side effects, and lower costs.

The company was founded in 2017 and headquartered in New York, United States.. .

CNS Therapeutics (Old)

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CNS Therapeutics is a private company based in St. Paul, Minn.

CNS Therapeutics develops and markets safe, high-quality pharmaceuticals for site-specific delivery to the central nervous system to treat neurological disorders and chronic pain. In addition to its first FDA-approved product, Gablofen, CNS Therapeutics is currently collaborating with U.S.

and international scientific experts to develop and test new treatments for pain and Parkinson’s disease.. .

Clockwork Tech

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Clockwork Tech is the Internet,communications,mobile phone,industrial design and advertising industries.

Thinking Engines

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Thinking Engines provides the commercial construction industry with a connected construction technology.

MetaModix

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MetaModix manufactures surgical and medical instruments for the treatment of metabolic disease and Type II diabetes. The company’s first product, the EndoSleeve is designed to be a safer and more cost-effective treatment option for patients suffering from Type 2 Diabetes, NASH, and Obesity.

It was founded in 2009 and is headquartered in Plymouth, Minnesota, United States.. .

LiquidCool Solutions

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LiquidCool Solutions provides a patented total liquid submersion technology that introduces an eco-friendly di-electric liquid into virtually any electronic device for operation in any environment. With the elimination of fans and the internal components fully submerged, LiquidCool Solutions’ technology offers benefits that air and fan-based cooling as well as other forms of liquid cooling simply cannot duplicate.

LiquidCool Solutions was co-founded by Daren Klum and Chad Attlesey in 2006 and it is headquartered in Rochester, Minnesota.. .

RoverMed BioSciences

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RoverMed develops precision targeted drug delivery technology aimed at delivering life saving drugs to the most challenging diseases in hard to reach places in the body. RoverMed has developed targeted, twenty nanometer nanocapsule technology capable of reaching the most challenging disease sites and delivering cargo – intact – into the nucleus of target cells, regardless of where these cells are located in the body.

RoverMed’s nanocapsule technology has been proven, through years of intensive research and development, by Minnesota-based GeneSegues Therapeutics. A precision target drug delivery platform has been developed initially for solid tumor cancers of the head and neck, prostate, and colon.

RoverMed is now applying this technology toward a broader spectrum of treatment applications, in partnership with larger drug developers, in order to expand the acceptance, use and impact on a host of new, exciting applications. Our business model includes partnering our drug delivery technology with our partner’s drugs to advance novel therapeutics aimed at treating some of the most challenging diseases that are not well served by traditional therapeutic options..

Aurora Pharmaceutical

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Aurora Pharmaceutical is a veterinary company that develops and manufactures veterinary pharmaceutical products. It provides livestock and companion animal products, such as wound spray with pain relief, livestock wound care, waterless surgical prep, and chlorhexidine gluconate concentrate solutions.

The company offers its products in the form of liquids, tablets, capsules, gels, and powdered products. It sells its products through distributors.

The company was incorporated in 2009 and is based in Northfield, Minnesota.. .

GT Urological

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GT Urological, LLC develops, manufactures, distributes, and markets medical devices for the urinary incontinence market. It offers surgical implants, which restore urinary control to sufferers of long-term stress urinary incontinence; and ActiCuf, a disposable and undetectable pouch to help men treat and manage light to moderate urinary incontinence.

The company offers its products through distributors and retailers in the United States and Canada. GT Urological, LLC was founded in 2002 and is based in Minneapolis, Minnesota..

Pelvital

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Pelvital is a privately held company that restores Pelvic Health and improve the lives of people. They are currently evaluating the Flyte system, an investigational device designed to strengthen and potentially heal the pelvic floor muscle system, using a unique technology capable of delivering mechanotherapy.

It was founded in 2016 and headquartered in Minneapolis, Minnesota.. .

Protégé Biomedical

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Protégé Biomedical is a company with a unique new line of hemostatic products developed to stop bleeding in animals and humans*. Their hemostatic devices use a patent-pending compound of all-natural minerals designed to quickly stop bleeding in minor to severe wounds.

Protégé Biomedical will launch their first product, ClotIt, in September. ClotIt is a powder designed to stop bleeding in minor-to-severe animal wounds.

*Military, Surgical, and general consumer products are currently in development.. .

Biomedix vascular solution

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Founded in 1997, BioMedix is a leader in Health Information Technology (HIT) software, products and services that connect primary care providers, vascular labs, vascular specialists and healthcare systems in a continuum of collaborative care. We provide the only integrated suite of hardware, software and online services designed to cost-effectively detect vascular disease.

Our award-winning suite of medical devices, advanced practice management and Electronic Health Record (EHR) software and web-based solutions give providers a more complete view of patient care. BioMedix products are designed to share information and work together in a continuum of care.

PADnet® and VEINnet™ devices for in-office vascular testing for the early detection of arterial and venous disease. TRAKnet® PM – DPM Edition integrated electronic health records (EHR) and Advanced Practice Management Solutions.

TRAKnet Lab software improves lab efficiency and supports IAC (Vascular Testing) accreditation. TRAKnet Outcomes tracking software improves financial and therapeutic outcomes.

PADnet Disease Management System 2.0 for developing best practices for vascular planning and growth. Technological innovation, a deep understanding of vascular care and concern for the needs of patients have made BioMedix the leading provider of integrated solutions for non-invasive vascular diagnostics and vascular lab management.

Medical professionals can analyze clinical data and patient demographics to get a complete picture of vascular health. The result is faster and better diagnosis of vascular disease..

Insitu Biologics

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InSitu Biologics is a developer of a drug delivery platform designed to focus on development of new and proprietary treatments.

Nirva Medical

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Nirva Medical is a medical device start up focusing on organ-specific therapy-delivery technology for various clinical applications.

Hennepin Life Sciences

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Hennepin Life Sciences is a growth stage human and animal health company that is uniquely focused on the development of patent protected, novel, naturally-derived anti-infective compounds for the prevention and treatment of a wide array of infections. We created innovative nature-based therapies by combining molecular concepts of infection to clinical applications.Founded in 2009 from a technology transfer out of the University of Minnesota, Hennepin Life Sciences (HLS) is a Phase2 clinical trial stage, Minnesota -based biotechnology firm that continues to develop a patented approach to address the global super bug challenge.

Today, HLS continues to expand its product platform intellectual property, advance the practical science through clinical studies and is active forging distribution partnerships to initially reach clinical application.. .

Uromedica

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Uromedica Inc. is a Minnesota based medical device company that has developed an adjustable balloon device for stress urinary incontinence (SUI) for both male and female patients.

We have been in business since 1997 and have had CE Mark approval since 2002. We are considered a late stage start up and have a unique and effective product that has been implanted in nearly 11,000 patients worldwide with excellent results.

Hypertension Diagnostics

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Hypertension Diagnostics, Inc. designs, develops, manufactures, and markets proprietary noninvasive medical devices that detect subtle changes in the elasticity of arteries in the United States and internationally.

Its patented CVProfilor allows a physician to non-invasively assess the elasticity of small and large arteries, of which small artery elasticity is the earliest and sensitive marker of cardiovascular disease. The company offers CVProfilor DO-2020, which provides a patient’s arterial elasticity indices used in the assessment for underlying vascular disease; CVProfilor MD-3000 that offers a sensitive and specific guide to the presence of blood vessel disease; and HD/PulseWave CR-2000 research cardiovascular profiling system for research purposes.

Its products collect 30 seconds of blood pressure waveform data, perform an analysis of the digitized blood pressure waveforms, and generate a CVProfile report that contains information on blood pressure, heart rate, pulse pressure, body surface area, body mass index, and both C1-large and C2-small artery elasticity indices. The company sells its products to primary care physicians, cardiologists, health care professionals, trained medical personnel, research investigators at academic medical research centers, government institutes, cardiovascular specialists, and pharmaceutical firms.

It markets its products through a representative organization in the United States. Hypertension Diagnostics, Inc.

was founded in 1988 and is headquartered in Eagan, Minnesota.. .

Peytant Solutions

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Peytant Solutions, Inc. is a regenerative medical device company, incorporating human biomaterial with absorbable and alloy implant technologies.

Their catheter delivered, biologic implants offers regenerative solutions for patency, barriers and a rapid bio-integration in the treatment of all luminal diseases.. .